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Bournemouth Univeristy Production. Directed by Dave Spragg. Cast: Steve White. Filmed Sep 2009

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“Soundmapping The Genes” is a project involving music composition and improvisation based on biological data – the complete DNA genetic code of the H1 histone protein of the rainbow trout. For more info, please visit: www.soundmappingthegenes.com

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Many HIV-infected patients have adverse reactions to anti-retroviral drugs, and others fail to take the drugs properly, which means resistance to the drugs may increase. In Thailand, the government plans to provide free DNA testing to screen for adverse reactions, to help reduce the threat of resistance.

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Chemicals causing various types of alkylation (methylation, ethylation etc.) of DNA bases are widespread mutagens and carcinogens. The most mutagenic lesion is O6-methyl-guanine that could be paired with cytosine or thymine evading the proof-reading capacity of a high-fidelity DNA polymerase. This video shows various steps of replication involving O-6-methylguanine and thymine pairs (ref. Warren et al. PNAS, v103, [...] Continue Reading…